Dennis B. Costello

Renal Solutions, Inc. develops, manufactures and distributes medical devices for dialysis. It commercializes the Allient Sorbent Hemodialysis Systems, a technology/service solution for the chronic and acute dialysis market. The company was founded by Peter M. DeComo on August 1, 2000 and is headquartered in Warrendale, PA.

BioVex, Inc. develops vaccines for the treatment of cancer and the prevention of chronic infectious diseases. Its products include OncoVEX oncolytic and ImmunoVEX technology. The company was founded in 1999 by Dr. Robert Coffin and is headquartered in Woburn, MA.

CS-Keys is the leader in discovery and development of cancer diagnostics based on the science of the DNA Synthesome. As the greatest potential for reducing mortality of cancer lies in the detection of asymptomatic, early stage disease, as well as for residual disease after treatment, the discovery of new markers for this purpose holds significant promise. CS-Keys patented caPCNA antibody may be a powerful ally in helping pathologists achieve this objective. CS-Keys, Inc. is a private, Indianapolis-based biotechnology company focused on the discovery and development of 3rd generation cancer-associated biomarkers using proteomics. These biomarkers may be used to create products to enhance the diagnosis and treatment of patients with cancer. CS-Keys was founded in early 2006 to develop and commercialize products based on the founders research and licensed from Indiana University.

BioVex Group, Inc. operates as a clinical-stage biotechnology company. It focuses on the development and commercialization of targeted treatments for cancer and the prevention of infectious disease. The company was founded in 1999 and is headquartered in Woburn, MA.

Cardialen, Inc. develops medical devices. It offers pain-free cardio version therapy for atrial fibrillation (AF) using low-energy implantable atrial cardioverters. The firm develops and commercializes these as an independent specialist, to address major needs in atrial fibrillation management, achieve improved outcomes and reduce the risk of stroke, heart failure and high healthcare costs associated with atrial fibrillation. The company's products comprise implantable low-energy pain-free atrial cardioverters and cardiac leads and defibrillator equipment. Its products are used for the treatment of atrial and ventricular arrhythmias. Cardialen was founded in 2008 by D. Graeme Thomas, Randy H. Weiss and Igor R. Efimov and is headquartered in St. Louis, MO.

Aerpio Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company focused on advancing innovative therapies for vascular diseases. The firm develops small molecules and monoclonal antibodies for the treatment of vascular disease and enhancement of wound healing. Its two lead programs include a tie-2 activator for diabetic macular edema and vascular leak, and a hypoxia-inducible factor 1-a stabilizer for wound healing and the treatment of inflammatory bowel disease. The company was founded by Joseph H. Gardner and Robert Shalwitz in 2011 and is headquartered in Cincinnati, OH.

Euclises Pharmaceuticals, Inc. operates as a biopharmaceutical company. The firm develops a portfolio of COX-2 inhibitors optimized for cancer treatment based on its proprietary Euclicoxib platform and is in the process of selecting a lead clinical development candidate. The company was founded by John J. Talley in 2011 and is headquartered in St. Louis, MO.

BioVex Ltd. operates as a biotechnology firm. It focuses on the development and commercialization of biological treatments for cancer and the prevention of infectious disease. The company was founded on December 15, 1997 and is headquartered in Cambridge, the United Kingdom.

Case Western Reserve University provides educational services. It offers a variety of undergraduate degree courses and graduate and professional options such as arts and sciences, dentistry, engineering, law, management, medicine, nursing, social work, and more. The firm also offers dual-degree programs. The company was founded in 1826 and is headquartered in Cleveland, OH.

Global Factory, Inc. provides collaborative manufacturing execution systems. The firm's software gather, organize & analyze demand, production & quality data from various sources and monitor key indicators & execute business processes to control, manage & optimize distributed manufacturing operations. The company was founded in 1999 and is headquartered in Santa Clara, CA.

Spring Mill Venture Partners (Spring Mill) is a venture capital firm founded in 2004 by Ken Green, Jane H. Martin and David O. Mann. The firm is headquartered in Carmel, Indiana.

BioOhio is a non-profit organization that connects and serves Ohio's bioscience community to drive success in improving the quality of life. The non-profit company is based in Columbus, OH. With over 300 member organizations that employ over 100,000 people, BioOhio provides member-guided services that include networking, advocacy, events, talent, information, and cost savings. BioOhio is the state affiliate for bioscience associations such as Advamed, Bio, PhRMA, and more. Eddie Pauline has been the CEO of the company since 2021.

Part of Battelle Memorial Institute, Battelle Corp. provides atmospheric research. The company is based in Columbus, OH. Lewis F. von Thaer has been the CEO of the company since 2017.

Juventas Therapeutics, Inc. provides regenerative therapies for cardiovascular disease. It is a clinical-stage biotechnology company developing a pipeline of factor-based regenerative therapies to treat life-threatening diseases. The company's product has been shown to protect and repair tissue following ischemic injury by recruiting the body's own stem cells to the damaged tissue. The company was founded by Rahul A. Aras and Marc S. Penn in 2007 and is headquartered in Cleveland, OH.

CincyTech LLC (CincyTech) is a venture capital firm founded in 2007. The firm is headquartered in Cincinnati, Ohio.

Global Cardiovascular Innovation Center operates as a cardiovascular research and product development consortium. It focuses on the formation, attraction, expansion and retention of cardiovascular companies to create jobs and facilitate economic development in the State of Ohio. The company was founded in 2007 and is headquartered in Cleveland, OH.

Airway Therapeutics, Inc. operates as a pharmaceutical company which specializes in the development of surfactant-related products. The firm offers products for the prevention of bronchopulmonary dysplasia, as well as for the treatment of pulmonary infections associated with cystic fibrosis. It also provides pediatric drug development, orphan drug development, pulmonary therapies, protein drug development, neonatal drug therapy, and inhalation drug delivery. The company was founded by Charles McOsker in 2011 and is headquartered in Cincinnati, OH.

Arch Oncology, Inc. develops drugs for life-threatening disorders. Its products include anti-CD47 monoclonal antibody, CD47 antisense oligonucleotide, and a small molecule CD47 inhibitor. The company was founded by William A. Frazier and Jeffrey S. Isenberg in 2006 and is headquartered in Brisbane, CA.

Enable Injections, Inc. develops wearable bolus injectors for investigational use in the pharmaceutical and biotechnology industries to deliver high viscosity, high volume payloads up to 20cc to the subcutaneous tissue. The company was founded by Michael D. Hooven in February 2010 and is headquartered in Cincinnati, OH.

Eccrine Systems, Inc. develops sweat sensor technologies. It is developing non-invasive, disposable, electronic patches that measure and transmit real-time data about human sweat. The company was founded by Robert Beech and Jason Heikenfeld on November 25, 2013 and is headquartered in Cincinnati, OH.

Genetesis, Inc. provides medical devices. Its technology utilizes the body’s weak magnetic fields to reconstruct, computationally, areas of high and low electrical conductivity in the heart. The firm also offers computational medicine, electrophysiology and diagnostics services. The company was founded by Peeyush Shrivastava in 2013 and is headquartered in Cincinnati, OH.

Standard Bariatrics, Inc. operates as a surgical procedure company focused on the development and commercialization of medical devices. It offers STANDARD CLAMP, a laparoscopic surgical device designed to clamp the entire length of the stomach, enabling surgeons to plan and hold the staple line prior to dividing the stomach during laparoscopic sleeve gastrectomy. The company was founded by Jonathan Thompson in 2014 and is headquartered in Cincinnati, OH.

Xact Medical LLC develops medical devices. The firm develops Fast Intelligent Needle Delivery (FIND) system which will give clinicians a device to more precisely, quickly and conveniently place an object such as a needle tip in the body, reducing uncomfortable and time consuming trial and error. The company was founded in September 2016 and is headquartered in Cincinnati, OH.

Myonexus Therapeutics, Inc. operates as a clinical stage company. It engages in the research and development of limb-girdle muscular dystrophy gene treatments. The company was founded by Michael Triplett and Bruce Halpryn in February 2017 and is headquartered in New Albany, OH.

Neurotechnology Innovations Translator LLC develops and commercializes pioneering neuro-technology solutions. The private company is based in Columbus, OH.

Avation Medical, Inc. provides platform for wearable nerve stimulation systems. The company is headquartered in Columbus, OH.

Kurome Therapeutics, Inc. develops therapies that target cancer cells. The company was founded by Daniel Starczynowski and is headquartered in Cincinnati, OH.

Armatus Bio, Inc. is a biotechnology company that operates at the intersection of genetic science and bioengineering. The company is based in Columbus, OH. The company was founded by Peter G. Kleinhenz, Michael Triplett. Michael Triplett has been the CEO since incorporation.