Azzurra Caltagirone is a businessperson who has been at the helm of 15 different companies. Presently, she occupies the position of Chairman at Caltagirone Editore SpA, Chairman of Il Gazzettino SpA, Chairman at La Piemme SpA and Chairman at Stampa Roma 2015 Srl (which are all subsidiaries of Caltagirone Editore SpA), Chairman of Quotidiano di Puglia SpA, Chairman at Corriere Adriatico Spa, Chairman for Stampa Napoli 2015 SRL, Chairman of Stampa Venezia Srl, Chairman for Servizi Italia 15 SRL, Chief Executive Officer for Leggo SpA, President for Piemme SpA Concessionaria DI Pubblicita', Chairman of Finanziaria Italia SpA, Chairman at FGC SpA and Chief Executive Officer for Il Messaggero SpA. Azzurra Caltagirone is also on the board of 13 other companies.

In her past career she held the position of Chairman of Ads SRL.