William Closs

Solohill Engineering, Inc. researchs & develops microcarrier beads for cell and tissue culture industries. All currently available models have a solid core of either cross-linked polystyrene or modified polystyrene. Coatings such as glass, collagen (gelatin), cationic surface treatment, and recombinant proteins such as ProNectin® F are applied to promote attachment and growth of mammalian cells. The chemical constituents of the core can be adjusted to vary specific gravity from 1.02 – 1.10. These solid beads survive autoclaving up to 131° C and gamma irradiation with no deleterious effects. The company was founded in 1984 and is headquartered in Ann Arbor, MI.