John P. Dean

Velomedix is a development stage medical device company created to realize the clinical potential of mild therapeutic hypothermia in benefiting patients suffering from ischemic and reperfusion injury effects of cardiac arrest, heart attack, stroke and traumatic brain injury. A comprehensive review of the medical literature demonstrates that cooling protects cells at risk, prevents tissue death and preserves organ function. Therapeutic Hypothermia offers a novel solution for the protection of the body's organs during ischemic insults and later from reperfusion injury. Cooling protects tissue during ischemia by reducing oxygen metabolism, inflammation and maintaining cell membrane integrity. In the case of reperfusion injury hypothermia reduces oxidative stress, micro vascular clogging, free radical production and inflammatory responses which are destructive to cells that have had blood flow restored after a period of ischemia.

EndoTex Interventional Systems, Inc. develops and manufactures medical devices. It provides invasive medical devices used for treatment of carotid artery disease. The company develops interventional vascular therapeutic solutions that reduces the need for re-intervention. EndoTex Interventional Systems was founded by Ulrich Sigwart and Mark Wholey in 1995 and is located in Cupertino, CA.

Cryovascular Systems, Inc. used to develop therapy products for the treatment of peripheral vascular and cardiovascular diseases. The company products were includes non-saline angioplasty devices for arterial catheterization. Cryovascular Systems was founded by James Joye & Ronald Williams in 1977 and was headquartered in Los Gatos, CA

Embolic Protection, Inc. develops proprietary filters that capture embolic material that is dislodged during cardiovascular surgery.